NIHR BTRU in Donor Health and Genomics - Events
Seminars take place in the seminar rooms at Strangeways Research Laboratory, 2 Worts' Causeway, Cambridge CB1 8RN
For further information please contact firstname.lastname@example.org
Monday, 20 May 2019 13:00 - 14:00
Topic: Hemolysis markers in donors and recipients: Findings from the REDS-III RBC-Omics and Brazil Sickle Cell Disease Cohort Studies
Hemolysis is the rupturing of red blood cells and it can lead to additional health problems for recipients of blood transfusion and for patients who are at risk for this to occur whether or not they are transfused. The US National Heart, Lung, and Blood Institute, Recipient Epidemiology and Donor Evaluation Study (REDS-III) enrolled donors for extensive studies of factors predicting hemolysis as part of the RBC-Omics study conducted in US blood donors. In a parallel study in Brazil, a large sickle cell disease (SCD) cohort was enrolled to understand disease outcomes and the role of transfusion in patient care. Genetic characteristics of both RBC-Omics donors and the SCD cohort in Brazil were determined by examining short pieces of DNA using array technology. This transfusion medicine array was developed for REDS-III and covers approximately 800,000 genetic features that could be related to hemolysis. This talk will review the key findings related to predictors of hemolysis in blood donors and SCD patients by comparing the genetic features and clinical measures of health in both groups, including the role of a combination of genetic features that when considered together may better predict hemolysis in donated blood and transfusion recipients.
Dr Brian Custer, Director of Epidemiology and Policy Science at the Blood Systems Research Institute, Vice President of Research and Scientific Affairs at BloodSystems and an Adjunct Professor in the Department of Laboratory Medicine at the University of California, San Francisco.
Dr Custer conducts research on the epidemiology and health economics of the blood supply and transfusion medicine policy throughout the world, primarily focused on infectious diseases, donor health and recipient outcomes.
Friday, 21 June 2019 13:00 - 14:00
Topic: Whole genome sequencing in diverse samples reveals large effect, population specific
Many complex human traits demonstrate considerable allelic heterogeneity across genetically diverse populations. The Trans Omics for Precision Medicine (TOPMed) program, sponsored by the US National Institutes of Health (NIH), has generated whole genome sequence data on over one hundred thousand individuals across a diverse set of US minority populations. In analyzing these data for associations with quantitative traits, we have identified numerous associations with population specific alleles. In this talk, we will present findings from several association studies in TOPMed where population specific alleles have allowed us to identify the causal variants at multiple loci.”
Dr Paul Auer, University of Wisconsin-Milwaukee
Dr Auer’s primary research is focused on discovering the genetic determinants of common chronic diseases including heart disease, bleeding disorders, type II diabetes, stroke and colorectal cancer. Specifically, he develops and implements statistical and computational tools for analysing genetic data from large US health studies. He is currently studying the extent to which rare genetic variation influences disease risk in diverse US populations.
Monday, 16 September 2019 13:00 - 14:00 (TBC)
Dr Andrew Johnson, Investigator at National Heart, Lung and Blood Institute, USA
“Dr Johnson’s laboratory research focuses on understanding genetic and genomic underpinnings of individual variability in therapeutically targeted cardiovascular disease (CVD) pathways. In particular, his work focuses on understanding individual variability in platelet development, function, and response to treatment. Dr Johnson is interested in the pharmacogenetics of anti-platelet treatments and resulting CVD outcomes. His laboratory applies population-scale approaches to the problem including genetic studies, collaboration with clinician-scientists, studies of gene expression variability in human tissues, and bioinformatics and systems biology approaches. Additionally, the Johnson laboratory creates and applies cutting edge genomic and bioinformatics resources.”
Saturday, 13 October 2018 10:00 - 16:00
BTRU Past Event
Hills Road Sixth Form College – Big Biology Day
The Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics is dedicated to discoveries and advances in the field of blood research. Join us at Hills Road Sixth Form College to find out about blood groups, the blood donation process and what we’re learning to benefit the health of the UK population. We will be exhibiting with the BTRU in Organ Donation and Transplantation.
Big Biology Day (BBD) Cambridge is one of the biggest, free biology public engagements events in the country. It brings together the Cambridge biology community and national biology organisations to engage the public in our subject. Big Biology Day
Monday, 26 November 2018 13:00 - 14:00
BTRU Past Event
Topic: Iron depletion in high school-age blood donors: what do we know, and what should we do about it?
Recent research shows that many blood donors have intermediate or advanced iron depletion, with the latest data indicating a greater susceptibility for iron depletion in donors 16 to 18 years old. In this talk, Dr Spencer will review the impact of blood donation on blood donor iron status, motivation for concerns in younger donors, and the operational and regulatory considerations attendant to potential mitigation measures.
Dr Bryan Spencer, Research Scientist at the American Red Cross
Dr Spencer has an extensive background in epidemiology / public health, infectious disease, study design, management, data analysis and blood safety issues, including in an international context.
Thursday, 13 December 2018 13:00 - 14:00
BTRU Past Event
Topic: Sickle cell disease: when simple meets complex
Sickle cell disease is a simple monogenic blood disorder, yet it is characterized by extreme clinical heterogeneity. In this talk, I will describe how we are using modern complex trait genetic and functional genomic approaches to better understand the genetic causes of this heterogeneity. I will also present recent work focused on the functional characterization of genetic variation associated with blood-cell phenotypes.
Dr Guillaume Lettre, Associate Professor of Medicine at the Montreal Heart Institute and the Université de Montréal
Dr Lettre’s lab uses human genetic and functional genomic approaches to understand the causes of cardiovascular and hematological diseases.
Monday, 4 February 2019 13:00 - 14:00
BTRU Past Event
Topic: The RESTORE (Recovery and Survival of Stem Cell Originated Red Cells) clinical trial
“There are a small number of patients with rare blood group types for whom NHS Blood and Transplant (NHSBT) cannot meet the transfusion requirements. New red blood cells can be grown from human blood stem cells in the laboratory. This trial will assess, in healthy volunteers, the recovery and survival of a mini-dose of red blood cells derived from CD34+cells isolated from adult blood vs standard donated red blood cells. We hope that this will provide us with a novel transfusion product for these patients in the future, some of whom require regular transfusions throughout life (e.g. for thalassemia or sickle cell disease).”
Dr Cédric Ghevaert, Consultant Haematologist at NHSBT and Senior Lecturer in Transfusion Medicine (University of Cambridge)
Dr Ghevaert’s research focuses on the production of blood cells from pluripotent stem cells with the declared aim to produce novel cellular therapies for transfusion to patients. He has a keen interest in inherited platelet disorders (such as Thrombocytopenia with Absent Radii) using the pluripotent stem cell technology for disease modelling.
Thursday, 14 March 2019 19:00 - 20:00
BTRU Past Event
Written in Blood: What can blood cells tell us about health and disease?
In the UK, 1.1m people donate blood annually, directly saving lives through transfusion—but, blood can do so much more. Emanuele Di Angelantonio, Professor of Blood Donor Health, Dr Will Astle and Lisa Schmunk will discuss how blood donors contribute to the health of everyone in the population by participating in studies which link environmental and genetic factors with properties of the blood. These studies help us understand the role of blood in diseases such as heart attack and stroke. This research is conducted by the National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics, in partnership with NHS Blood and Transplant (NHSBT), to advance the field of blood donor health and research. A short discussion (Q&A period) will follow the talk.
Please join us at 18:00 for the lecture ‘Organ Transplantation: past successes, future challenges’, given by members of the BTRU in Organ Donation and Transplantation. Book your place.
Venue (for both lectures): Mill Lane Lecture Room 1, 8 Mill Lane, Cambridge CB2 1RW
Image Copyright: Karl-Ludwig Poggemann, Electron Microscopy Facility at The National Cancer Institute at Frederick (CC BY 2.0). The name of the Facility was removed from the image.
Wednesday, 20 March 2019 13:00 - 14:00
BTRU Past Event
Topic: Developing a tiered consent process for individuals recruited to longitudinal biobank research using a case study of NHS blood donors
“Consent to longitudinal (over time) biobank research poses a number of challenges for traditional informed consent models, which tend to assume that participants are consenting to specific, well-bounded studies with readily identifiable risks. Biobanks are better understood as a form of infrastructure or research resource. This study aims to develop the content for a tiered consent process which can be used in NHS Blood and Transplant (NHSBT) routine blood donation sessions to recruit healthy blood donors to the NIHR Blood and Transplant Research Unit (BTRU) in Donor Health in Cambridge and the national NIHR BioResource for Translational Research. The study will involve engagement and partnership with key stakeholders, including researchers, healthy volunteers, patients, operational staff, clinical care teams and the public.”
Dr Jenni Burt, Senior Research Associate (University of Cambridge) and Senior Social Scientist (THIS Institute). Jenni’s research focuses on improving the quality of interactions between patients and health care professionals, and in exploring and reducing variations in the quality of care.
Dr Natasha Kriznik, Research Associate (University of Cambridge and THIS Institute). Natasha’s main research interests relate to medical sociology, particularly health inequalities and public health, as well as the processes related to the production of social policy. She is also interested in social theory and its use in enhancing the outcomes of research.
Sunday, 24 March 2019 11:00 - 16:00
BTRU Past Event
How can blood donations be used in research?
The BTRU in Donor Health and Genomics works closely with NHS Blood and Transplant to maintain stocks of blood whilst looking after donor health. This has been achieved through studies such as INTERVAL (frequency of blood donation) and COMPARE (methods for measuring haemoglobin).
Join us for fun, hands-on activities to learn more about the blood donation process, blood groups and what our scientists are discovering to benefit the health of the UK population. More info.
This event is in partnership with Awesome Organs, organised by the BTRU in Organ Donation and Transplantation, as part of the Cambridge Science Festival’s Biomedical Campus Hands-on Day.
Venue: Cambridge Academy for Science and Technology, Robinson Way, Cambridge CB2 0SZ