Stratified approaches to blood donation

This theme of research aims to make blood donation safer and more sustainable by developing personalised approaches to donation, such as tailoring the inter-donation interval to the capacity of donors to give blood safely. Whereas Theme 1 and Theme 2 will investigate aetiological relationships (the causes(s) of a disease or condition), Theme 3 will integrate multi-biomarker data to develop predictive stratified approaches to donation in order to enhance donor health while ensuring the blood supply is maintained.

Projects currently being undertaken by colleagues at the University of Cambridge and the University of Oxford:

  • Using genomics to improve transfusion safety
  • Using genomics to develop stratified approaches to blood donation
  • Improving adherence for blood donation appointments
  • Determinants of return behaviour in the blood donor
  • Predictors of deferral for low haemoglobin


Theme 3 is led by Dr Angela Wood, University of Cambridge.

Angela Wood
Lois Kim
Tom Bolton
Andrew Browne
Yuejia Xu






Research staff: Dr Lois Kim

Trainees: Tom Bolton, Andrew Browne, Yuejia Xu


Medical Research Council-Biostatistic Unit (MRC-BSU)

NIHR BioResource

NIHR Cambridge Biomedical Research Centre


Utilising data from the INTERVAL and COMPARE studies and results from Themes 1 and 2, Theme 3 will build models to help predict how often individual donors should give blood. This will ensure donor health, whilst maximising the amount and type of blood collected by NHSBT.


Lane WJ, et al. Automated typing of red blood cell and platelet antigens: a whole-genome sequencing studyLancet Haematol. 2018 May.

Di Angelantonio E, et al. Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donorsLancet. 2017 Nov 25; 390(10110):2360-2371.